Human Recombinant IL-2 is a monomeric cytokine first identified as a T cell growth factor. It binds to a heterotrimeric IL-2 receptor complex (CD25, CD122, and CD132) on immune cells. This interaction triggers JAK3, STAT5, and AKT signaling pathways that drive cell proliferation and survival. Most IL-2 is secreted by activated CD4+ and CD8+ T cells, with smaller amounts produced by B cells and dendritic cells.
At Apex Scientific, a leading laboratory equipment supplier in South Africa, we provide high-purity Human Recombinant IL-2 (≥ 95% purity) from StemCell Technologies. Manufactured to stringent quality standards, it ensures consistent performance in immunology and stem cell biology research across South Africa.
Role in Immune Regulation
Human Recombinant IL-2 regulates immune responses in several ways. It prevents autoimmunity during T cell development in the thymus by promoting regulatory T cell growth (CD4+ CD25+). It also influences the formation of follicular helper T cells, which support B cell function and antibody production. Furthermore, IL-2 helps control inflammation by inhibiting the differentiation of pro-inflammatory Th17 cells.
Researchers have observed elevated IL-2 levels in diseases such as scleroderma, rheumatoid arthritis, and certain cancers, including gastric and non-small cell lung cancer. However, no disease has been directly linked to a complete deficiency or excess of IL-2.
Applications and Specifications
Human Recombinant IL-2 is a high-purity cytokine used to stimulate T cell proliferation and activate NK cells. It supports hematopoietic progenitor cells and is a standard supplement in T cell culture protocols. In South Africa, researchers use it for experimental assays, immune function studies, and cell therapy development.
- Subtype: Cytokine
- Purity: ≥ 95%
- Cell Types: CD4+ T cells, CD8+ T cells, NK cells, hematopoietic progenitors
- Research Areas: Immunology, Stem Cell Biology
This cytokine integrates easily into workflows using standard laboratory equipment. Scientists across South Africa trust Apex Scientific for reliable supply, technical support, and expertise. For further resources, visit the Apex Scientific Insights page.
