Large Laboratory Bioreactor – Genesis

The large laboratory bioreactor or fermenter from Solaris Biosystems offers a versatile, compact solution for advanced laboratory fermentation. This stirred, autoclavable system supports both single and parallel operations, with SIP (Steam in Place) capabilities ensuring reliable, in-situ sterilization for consistent fermentation outcomes. Designed for aerobic and anaerobic processes, the GENESIS bioreactor integrates seamlessly into laboratory equipment setups in South Africa, providing precise control for reproducible results.

Ideal for research teams requiring flexible bioreactor configurations, this system enhances efficiency while maintaining aseptic conditions. Explore Apex Scientific’s full range of bioreactors and fermenters, and learn more about best practices and applications here.

The large laboratory bioreactor or fermenter systems from Solaris Biosystems provide versatile, high-performance solutions for laboratory fermentation. Designed for both single and parallel operations, these stirred, autoclavable bioreactors include in-situ sterilization (SIP). This feature allows reliable sterilization of harvest and sample lines throughout the fermentation process. Available in 7.5, 10, 15, and 20 L capacities, the GENESIS bioreactor supports aerobic and anaerobic fermentations. It ensures closed aseptic operation, making it ideal for research laboratories in South Africa seeking precise, reproducible results.

 

Efficient Sterilization and Temperature Control

The GENESIS system uses steam, electrical heaters, or a hybrid steam/electrical method for sterilization. Additionally, jacketed designs on the side and bottom enhance heat transfer and maintain optimal temperature control. The AISI 316L stainless steel vessel supports microbial and cell culture configurations, including Toro spargers, Rushton impellers, Marine impellers, and baffles. These options increase flexibility for various fermentation applications.

 

Advanced Monitoring and Automation

Digital Modbus sensors minimize background noise and provide rapid response times. Moreover, comprehensive measurement and control options accommodate batch, fed-batch, and continuous processes. Gas mixing strategies support up to five TMFC, and brushless motors ensure precise stirring. Optional analog I/O connections and a wheeled skid improve workflow and system flexibility.

 

Integrated Software for Parallel Management

Solaris Biosystems’ Leonardo SCADA software allows up to 24 bioreactors to run in parallel from a single HMI. Users can access real-time 3D views, manage profiles, assign peristaltic pump functions, and export data in .csv format. Furthermore, remote monitoring is possible via PC, tablet, or smartphone, improving workflow efficiency.

Explore Apex Scientific’s Insights page to learn more about large laboratory bioreactors and fermenters. Contact us today to discuss your laboratory equipment requirements.

ModelGenesis 7.5Genesis 10.0Genesis 15.0Genesis 20.0
Total Volume (L)7.5101520
Ratio H/D2.5/1
Min working volume (L)1.82.53.75
Max working volume (L)5.67.511.215
Max temperature135 °C
Operating pressureMax 1.9 bar(g) controllable up to 1.6 bar(g)
DesignStainless steel jacketed vessel
MaterialsParts in contact with the process AISI 316 L – other parts AISI 304
FinishingAll parts in contact with the culture: Ra < 0.4 µm External: Ra < 0.6 µm (mirror polished)
PORTS AND CONNECTIONS
Vessel lidSafety valve + gas out, sparger, antifoam/level sensor, pressure sensor, SALAS, 3 removable baffles, glass window + lamp or spare ports
Upper side wallOverlay gas inlet, circular sight glass
Lower side wall4 hygenic sockets (pH, dO₂ and 2 spare probes), sampling valve, sensor PT100
Vessel bottomHarvest valve
Jacket in-outSteam in, steam out, water in, jacket in/out, 3 electrical heaters in, PT100 for jacket
STIRRINGS
DriveBrushless Motor
Speed (rpm)1 – 1500
Torque (Nm)0.8 (7.5 and 10 L) or 1.9 (15 and 20 L)
ImpellersSelect from: Rushton, Marine, Pitched blade
THERMOREGULATION
ControlPID Control – Accuracy 0.1 °C
ControlHeat exchangers and/or electrical heaters External steam generator and/or chiller required
GAS CONTROL & GAS MIXING
Sparger and overlay gas controlTMFC
Gas mixing (Air, CO₂, O₂, N₂)Up to 5 TMFCs in total
Sparger typeSelect from: toro type (ring), intered microbubbling
Gas outCondenser
INTEGRATED PERISTALTIC PUMPS
Quantity & Type4 Watson Marlow 114FD/DV
CONTROLLER
Master control moduleFrom 1 to 24 units – 35 x 35 x 35 cm
HMI with Leonardo softwareTouch screen PC, 24″ Color Monitor
TEMPERATURE
SensorPT100
Accuracy± 0.1 °C
Control systemMeasuring resident in Leonardo software
Control range0 – 150 °C
pH
SensorDigital sensor
Sensitivity57 to 59 mV/pH
Control systemMeasuring resident in Leonardo software
Control range0 – 14
Operating temperatureUp to 130 °C
Pressure range1 – 6 bar(g)
ActuatorCascade to stirring, gas control, feedings
dO₂
SensorDigital Optical sensor
Accuracy1 ± 0.05 %-vol, 21 ± 0.2 %-vol, 50 ± 0.5 %-vol
Control systemMeasuring resident in Leonardo software
Control range0 – 300 % saturation
Operating temperatureUp to 130 °C
Pressure range0 – 12 bar(g)
ActuatorCascade to stirring, gas control, feedings
ANTIFOAM/LEVEL
SensorConductivity based
ControlMeasuring resident in Leonardo software
REDOX (ORP)
SensorDigital sensor
Accuracy± 1%
Control rangeMeasuring resCident in Leonardo software
Control range (mV)± 1500 mV
Operating temperatureup to 140°C
Pressure range0–20 bar(g)
CONDUCTIVITY
SensorDigital sensor
Accuracy± 3 at 1 µS/cm (1–100 µS/cm), ± 5 at 100–300 mS/cm
Control rangeMeasuring resident in Leonardo software
Control range (mS/cm)0–1000 mS/cm
Operating temperatureup to 140°C
Pressure range0–20 bar(g)
dCO₂
SensorDigital sensor
Accuracy± 10% of the reading
Control rangeMeasuring resident in Leonardo software
Control range (% CO₂)0–100% CO₂
Operating temperatureup to 140°C
Pressure range0–20 bar(g)
CELL DENSITY
SensorDigital sensor
Accuracy± 5% of the reading
Control rangeMeasuring resident in Leonardo software
AU range0–4 AU
VCD control range0–400 g/l
WEIGHT
SensorDigital sensor
Accuracy± 0.1 g (1 kg), ± 1 g (12 kg)
Control rangeMeasuring resident in Leonardo software
PERISTALTIC PUMPS
WM 120 ID Brushless1.6 l/min
WM 313 FODM175 rpm
WM 313 OEM VBM-D175 rpm

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