Why choose the LyoPilot S laboratory freeze dryer
LyoPilot S from Antech is a high-performance Laboratory Freeze Dryer designed for laboratories that require reliable pilot-scale Freeze Drying and Lyophilization. Available from Apex Scientific throughout South Africa, LyoPilot S combines compact dimensions with intelligent process control to support research, pharmaceutical development, biotechnology, and small-scale production. As an advanced Pilot Lyophilizer and Pilot Scale Freeze Dryer, LyoPilot S delivers accurate temperature control, efficient refrigeration, and automated vacuum management for consistent, reproducible results.
LyoPilot S single chamber design
The LyoPilot S features a compact single chamber design that delivers efficient freeze drying while minimising laboratory space requirements. The integrated ice condenser captures water vapour before it reaches the vacuum pump, helping shorten drying times while reducing pump contamination and maintenance. Furthermore, the system performs exceptionally well when processing products with low eutectic points or low collapse temperatures. Optional external vial connections also provide additional flexibility for specialised laboratory applications.
LyoPilot S Process Analytical Technology
LyoPilot S incorporates advanced Process Analytical Technology (PAT) tools to help laboratories optimise Freeze Drying cycles. The optional LyoTR sensor monitors both product temperature and electrical resistance, enabling accurate determination of freezing and eutectic points. Consequently, the controller can automatically regulate shelf energy during primary drying to reduce the risk of product collapse or thawing.
LyoPilot S shelf temperature control
Successful Lyophilization depends on consistent temperature control throughout the drying cycle. LyoPilot S incorporates stainless steel shelves with circulating silicone heat transfer fluid to provide excellent thermal conductivity and highly uniform temperature distribution. In addition, a pulse-type electronic expansion valve delivers rapid and precise shelf temperature regulation while minimising energy consumption. Temperature variation remains within 1°C across individual shelves and between shelf levels, improving batch-to-batch reproducibility. The standard hydraulic stoppering system also enables convenient vial sealing before samples leave the chamber.
LyoPilot S refrigeration and vacuum control
LyoPilot S combines an advanced refrigeration system with intelligent vacuum management to optimise Freeze Drying performance. The built-in ice condenser reaches temperatures as low as -90°C, while integrated condenser coils improve cooling efficiency and vapour capture. Hot gas defrosting prepares the system quickly for the next drying cycle, and the mechanical door lock simplifies routine cleaning.
The programmable vacuum control system allows users to define both the vacuum level and duration for every process step. A high-accuracy Pirani vacuum gauge measures vacuum down to 0.001 mbar, helping reduce drying time by up to 40%. Additionally, the system performs airtightness testing before processing and supports inert gas backfilling after Lyophilization, allowing vials to be sealed under controlled negative pressure for improved product storage.
The system also supports continuous product temperature monitoring using an ultra-fine Pt100 probe that provides excellent accuracy, corrosion resistance, and easy calibration. For additional process verification, an optional comparative pressure measurement system combines a Pirani vacuum gauge with a capacitive vacuum sensor. When both pressure readings converge below a predefined threshold, the controller automatically identifies completion of the primary drying stage, helping laboratories optimise process efficiency and reproducibility.
LyoPilot S with the LyoSMART+ controller
The intuitive LyoSMART+ controller simplifies both routine operation and process development. Its colour touchscreen provides clear process visualisation while supporting both automatic and manual operating modes. Users can create customised freeze drying recipes, store up to 30 user-defined programmes with 36 individual process steps, and monitor real-time process data throughout the drying cycle. USB and RS232 connectivity simplify data export, while password protection and configurable safety limits improve security and process control.
LyoPilot S for laboratories in South Africa
Whether you require a Laboratory Freeze Dryer, an advanced Pilot Lyophilizer, or a dependable Pilot Scale Freeze Dryer, LyoPilot S from Antech provides intelligent Freeze Drying and Lyophilization technology for pharmaceutical, biotechnology, research, and academic laboratories. Learn more in the Apex Scientific Insights section at, or contact Apex Scientific to discuss the most suitable pilot freeze drying solution for your laboratory in South Africa.
