Track cell proliferation, viability, morphology, and immune cell-mediated killing with the Maestro Z. Axion BioSystems Maestro Z platform offers impedance-based cell analysis for real time, continuous, label free monitoring of your cells. Continuous data reveals the kinetics of cell-cell interactions and cell-drug responses for better mechanistic understanding without the time- and cost-intensive process of repeating multiple endpoint assays. Now with a smartphone app allowing you to check on your experiment from outside the lab.
Key Features
Taking care of the assay so you can focus on the science.
- Monitor your experiments from outside the lab – The new Maestro Z App allows you to check in on your cells and experiment to ensure everything is running smoothly while you are away from the lab.
- Precisely control the cells environment – There is no need for an additional cell culture incubator, saving valuable lab space and money. Maestro Z’s smart environmental chamber finely controls temperature and CO₂ while rejecting electrical noise and mechanical vibrations.
- Continuous cell monitoring – 96 simultaneous live recordings from your cells. The Maestro Z system performs noninvasive electrical measurements from the cultured cell population, circumventing the use of dyes/reporters that can perturb your cell model and confound results. Track activity over hours and weeks from the same population of cells label free and in real time.
- See your cells – Maestro Z’s transparent CytoView-Z 96-well plates have a viewing window in each well, allowing for cell visualization and assay multiplexing.
- Start your assay with the push of a button – “One button setup,” means temperature and CO₂ levels automatically adjust on plate docking. Plate usage is logged via an integrated plate barcode scanner for convenient experiment tracking.
- Review your results faster – The Impedance module with AxIS Z software provides a simplified approach to the setup, execution, and analysis of experiments.
- Increase throughput with multiple Maestros – Continuously monitor multiple plates automatically and simultaneously with multiple Maestro support. Save space in your lab by controlling multiple Maestro systems using a single computer.
Overview
Cell-based assays enable rapid evaluation of human biology in vitro, with substantial advantages in throughput and cost over tissue or animal models. However, many cell-based assays are endpoint assays, limited to a single snapshot in time. Axion BioSystems’ Maestro Z platform offers impedance-based cell analysis for real time, continuous, label free monitoring of your cells. Continuous data reveals the kinetics of cell-cell interactions and cell-drug responses for better mechanistic understanding without the time- and cost-intensive process of repeating multiple endpoint assays.
The Maestro Z system is available with two software modules: Impedance and GxP Impedance. Select the software modules to match your assay needs:
Impedance – Track cell proliferation, morphology, and viability label-free and in real-time. Ideal for immuno-oncology, cytotoxicity, virology, cell migration, cell proliferation, GPCR assays, and many more.
GxP Impedance – Achieve FDA 21 CFR Part 11 compliance in GMP/GLP labs with this version of the Impedance Software Module.
Consumables
The Maestro Z system is compatible with the 96-well impedance assay plate.
CytoView-Z – The Maestro impedance plate with a transparent well bottom for cell visualization and assay multiplexing. Available in a 96-well plate format.
Related Applications
- Antiviral Drug Studies – Evaluate the antiviral effects of test compounds by tracking real-time changes in cytopathic effects
- Barrier Function – Monitor cell barrier integrity using a TEER (transepithelial or transendothelial resistance) assay
- Cancer Spheroid – Model complex solid tumor biology to investigate the in vitro effects of immunotherapies and other anticancer agents
- Cell Migration and Invasion – Track cell migration and proliferation for advanced metastatic cancer or wound-healing studies
- Cell Proliferation – Reveal the kinetics of cellular proliferation and for improved insights of cell models
- Cell Signaling – Measure the dynamics of GPCR cell signaling over minutes to hours label free
- Cytotoxicity and Cell Viability – Evaluate cell viability and characterize the cytotoxic properties of compounds in acute and chronic exposure experiments
- Immuno-oncology – Evaluate killing kinetics of immune cells (e.g. CAR T or NK) at physiologically relevant effector cell to target cell ratios
- Liquid Tumors – Study hematological cancer models with non-adherent cells to develop the next generation in blood cancer therapies
- Viral Titer – Quantify the infectious virus in a sample by monitoring the cytopathic effects in real time
